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KMID : 0352519830200030071
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Korea Univercity Medical Journal
1983 Volume.20 No. 3 p.71 ~ p.81
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Effects of Hysterectomy on the Retained Ovarian Function in Rabbit
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金善行/Kim, Sun-Haeng
羅重烈/李壽鍾/Na, Joong-Yol/Lee, Soo-Chong
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Abstract
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To understand effects cf hysterectomy cn tl:e retained ovarian function in the rabbits, pseudopregnancy was induced in seven rabbits, control group, by injection of 50 ttg of ethinyI estradiol and 100 IU of hCG subcutaneously.
And a week after hysterectomy of another sever rabbits, hysterectomized group, pseudo-pregnancy was induced with 50pg of ethinyl estradiol and loo IU of hCG.
The serum levels of progesterone and estrogen were determined every 3 day by radioimmunoassay and microscopic examination of the ovaries was performed in each group. Both findings in each grcup was compared and obtained following results.
1. Luteal phase in hysterectomized group was prolonged about 6 days compared to control group.
2. Histologic examination of ovaries revealed functional corpora lutea in hysterectomized group up to 30 days of experiment.
3. Serum estradiol level and histological picture of the ovarian follicles showed no significant differences between two groups during experiment.
4. These findings show that experimental hysterectomy has inhibitory effect on regressive change of the corpora lutes but has no effect on ovarian follicle.
These results suggest that PG is the luteolytic hormone in the rabbit.
But, it was presumely concluded that the result in estrogen showed which PGFza or some other substances in the uterus might be related to the mechanism of folliculogenesis in ovary according to references.
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